Metal-induced DNA translocation leads to DNA polymerase conformational activation

Binding of the catalytic divalent ion to the ternary DNA polymerase β/gapped DNA/dNTP complex is thought to represent the final step in the assembly of the catalytic complex and is consequently a critical determinant of replicative fidelity. We have analyzed the effects of Mg(2+) and Zn(2+) on the c...

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Detalhes bibliográficos
Main Authors: Kirby, Thomas W., DeRose, Eugene F., Cavanaugh, Nisha A., Beard, William A., Shock, David D., Mueller, Geoffrey A., Wilson, Samuel H., London, Robert E.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3326329/
https://ncbi.nlm.nih.gov/pubmed/22169953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr1218
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