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NMR Assignment of Polymerase β labeled with (2)H, (13)C, and (15)N in complex with substrate DNA

DNA Polymerase β is a multifunctional enzyme involved in base excision repair of nuclear DNA in vertebrate cells. It has been extensively studied as a model for mechanistic studies of the nucleotidyl transferase reaction, DNA synthesis fidelity, and protein-DNA interactions. Previous studies of (13)...

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Detalhes bibliográficos
Main Authors: Mueller, Geoffrey A., DeRose, Eugene F., Kirby, Thomas W., London, Robert E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2676717/
https://ncbi.nlm.nih.gov/pubmed/19421423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12104-007-9007-2
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