Mechano-chemical kinetics of DNA replication: identification of the translocation step of a replicative DNA polymerase

During DNA replication replicative polymerases move in discrete mechanical steps along the DNA template. To address how the chemical cycle is coupled to mechanical motion of the enzyme, here we use optical tweezers to study the translocation mechanism of individual bacteriophage Phi29 DNA polymerase...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Morin, José A., Cao, Francisco J., Lázaro, José M., Arias-Gonzalez, J. Ricardo, Valpuesta, José M., Carrascosa, José L., Salas, Margarita, Ibarra, Borja
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2015
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4402526/
https://ncbi.nlm.nih.gov/pubmed/25800740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv204
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