Replicative DNA polymerases promote active displacement of SSB proteins during lagging strand synthesis

Genome replication induces the generation of large stretches of single-stranded DNA (ssDNA) intermediates that are rapidly protected by single-stranded DNA-binding (SSB) proteins. To date, the mechanism by which tightly bound SSBs are removed from ssDNA by the lagging strand DNA polymerase without c...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Cerrón, Fernando, de Lorenzo, Sara, Lemishko, Kateryna M, Ciesielski, Grzegorz L, Kaguni, Laurie S, Cao, Francisco J, Ibarra, Borja
Format: Artigo
Language:Inglês
Published: Oxford University Press 2019
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6582349/
https://ncbi.nlm.nih.gov/pubmed/30968132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz249
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