Roles of DNA polymerase I in leading and lagging-strand replication defined by a high-resolution mutation footprint of ColE1 plasmid replication

DNA polymerase I (pol I) processes RNA primers during lagging-strand synthesis and fills small gaps during DNA repair reactions. However, it is unclear how pol I and pol III work together during replication and repair or how extensive pol I processing of Okazaki fragments is in vivo. Here, we addres...

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Detalhes bibliográficos
Main Authors: Allen, Jennifer M., Simcha, David M., Ericson, Nolan G., Alexander, David L., Marquette, Jacob T., Van Biber, Benjamin P., Troll, Chris J., Karchin, Rachel, Bielas, Jason H., Loeb, Lawrence A., Camps, Manel
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3167613/
https://ncbi.nlm.nih.gov/pubmed/21622658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr157
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