Roles of DNA polymerase I in leading and lagging-strand replication defined by a high-resolution mutation footprint of ColE1 plasmid replication

DNA polymerase I (pol I) processes RNA primers during lagging-strand synthesis and fills small gaps during DNA repair reactions. However, it is unclear how pol I and pol III work together during replication and repair or how extensive pol I processing of Okazaki fragments is in vivo. Here, we addres...

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Main Authors: Allen, Jennifer M., Simcha, David M., Ericson, Nolan G., Alexander, David L., Marquette, Jacob T., Van Biber, Benjamin P., Troll, Chris J., Karchin, Rachel, Bielas, Jason H., Loeb, Lawrence A., Camps, Manel
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2011
Teme:
Genome Integrity, Repair and Replication
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3167613/
https://ncbi.nlm.nih.gov/pubmed/21622658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr157
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