Active DNA unwinding dynamics during processive DNA replication

Duplication of double-stranded DNA (dsDNA) requires a fine-tuned coordination between the DNA replication and unwinding reactions. Using optical tweezers, we probed the coupling dynamics between these two activities when they are simultaneously carried out by individual Phi29 DNA polymerase molecule...

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Detalhes bibliográficos
Main Authors: Morin, José A., Cao, Francisco J., Lázaro, José M., Arias-Gonzalez, J. Ricardo, Valpuesta, José M., Carrascosa, José L., Salas, Margarita, Ibarra, Borja
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3361432/
https://ncbi.nlm.nih.gov/pubmed/22573817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1204759109
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