Active DNA unwinding dynamics during processive DNA replication

Duplication of double-stranded DNA (dsDNA) requires a fine-tuned coordination between the DNA replication and unwinding reactions. Using optical tweezers, we probed the coupling dynamics between these two activities when they are simultaneously carried out by individual Phi29 DNA polymerase molecule...

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Autors principals: Morin, José A., Cao, Francisco J., Lázaro, José M., Arias-Gonzalez, J. Ricardo, Valpuesta, José M., Carrascosa, José L., Salas, Margarita, Ibarra, Borja
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2012
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3361432/
https://ncbi.nlm.nih.gov/pubmed/22573817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1204759109
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