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Stringency of start codon selection modulates autoregulation of translation initiation factor eIF5

An AUG in an optimal nucleotide context is the preferred translation initiation site in eukaryotic cells. Interactions among translation initiation factors, including eIF1 and eIF5, govern start codon selection. Experiments described here showed that high intracellular eIF5 levels reduced the string...

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Detalhes bibliográficos
Main Authors: Loughran, Gary, Sachs, Matthew S., Atkins, John F., Ivanov, Ivaylo P.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3326321/
https://ncbi.nlm.nih.gov/pubmed/22156057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr1192
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