Suppression of protein aggregation by chaperone modification of high molecular weight complexes

Protein misfolding and aggregation are associated with many neurodegenerative diseases, including Huntington’s disease. The cellular machinery for maintaining proteostasis includes molecular chaperones that facilitate protein folding and reduce proteotoxicity. Increasing the protein folding capacity...

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Bibliografske podrobnosti
Main Authors: Labbadia, John, Novoselov, Sergey S., Bett, John S., Weiss, Andreas, Paganetti, Paolo, Bates, Gillian P., Cheetham, Michael E.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2012
Teme:
Original Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3326252/
https://ncbi.nlm.nih.gov/pubmed/22396390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/aws022
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