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Molecular chaperone-mediated rescue of mitophagy by a Parkin RING1 domain mutant
Mitochondrial dysfunction is characteristic of many neurodegenerative diseases. The Parkinson's disease-associated ubiquitin–protein ligase, Parkin, is important in the elimination of damaged mitochondria by autophagy (mitophagy) in a multistep process. Here, we show that a Parkin RING domain m...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3000674/ https://ncbi.nlm.nih.gov/pubmed/20889486 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq428 |
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