AMPK/ULK1-mediated phosphorylation of Parkin ACT domain mediates an early step in mitophagy

The serine/threonine kinase ULK1 mediates autophagy initiation in response to various cellular stresses, and genetic deletion of ULK1 leads to accumulation of damaged mitochondria. Here we identify Parkin, the core ubiquitin ligase in mitophagy, and PARK2 gene product mutated in familial Parkinson’s...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Hung, Chien-Min, Lombardo, Portia S., Malik, Nazma, Brun, Sonja N., Hellberg, Kristina, Van Nostrand, Jeanine L., Garcia, Daniel, Baumgart, Joshua, Diffenderfer, Ken, Asara, John M., Shaw, Reuben J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2021
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8026119/
https://ncbi.nlm.nih.gov/pubmed/33827825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abg4544
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