A STAT3-inhibitory hairpin decoy oligodeoxynucleotide discriminates between STAT1 and STAT3 and induces death in a human colon carcinoma cell line

BACKGROUND: The Signal Transducer and Activator of Transcription 3 (STAT3) is activated in tumor cells, and STAT3-inhibitors are able to induce the death of those cells. Decoy oligodeoxynucleotides (dODNs), which bind to the DNA Binding Domain (DBD) of STAT3, are efficient inhibitors. However, they...

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Main Authors: Souissi, Inès, Ladam, Patrick, Cognet, Jean AH, Le Coquil, Stéphanie, Varin-Blank, Nadine, Baran-Marszak, Fanny, Metelev, Valeri, Fagard, Remi
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2012
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3325846/
https://ncbi.nlm.nih.gov/pubmed/22423663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-11-12
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