Cellular response to alkylating agent MNNG is impaired in STAT1‐deficients cells

The S(N)1 alkylating agents activate the mismatch repair system leading to delayed G(2)/M cell cycle arrest and DNA repair with subsequent survival or cell death. STAT1, an anti‐proliferative and pro‐apoptotic transcription factor is known to potentiate p53 and to affect DNA‐damage cellular response...

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Detalhes bibliográficos
Publicado no:J Cell Mol Med
Main Authors: Ah‐Koon, Laurent, Lesage, Denis, Lemadre, Elodie, Souissi, Inès, Fagard, Remi, Varin‐Blank, Nadine, Fabre, Emmanuelle E., Schischmanoff, Olivier
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5020624/
https://ncbi.nlm.nih.gov/pubmed/27464833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.12887
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