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Cellular response to alkylating agent MNNG is impaired in STAT1‐deficients cells
The S(N)1 alkylating agents activate the mismatch repair system leading to delayed G(2)/M cell cycle arrest and DNA repair with subsequent survival or cell death. STAT1, an anti‐proliferative and pro‐apoptotic transcription factor is known to potentiate p53 and to affect DNA‐damage cellular response...
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| Pubblicato in: | J Cell Mol Med |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
John Wiley and Sons Inc.
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5020624/ https://ncbi.nlm.nih.gov/pubmed/27464833 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.12887 |
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