Amyloid-β/Fyn–Induced Synaptic, Network, and Cognitive Impairments Depend on Tau Levels in Multiple Mouse Models of Alzheimer's Disease

Alzheimer's disease (AD), the most common neurodegenerative disorder, is a growing public health problem and still lacks effective treatments. Recent evidence suggests that microtubule-associated protein tau may mediate amyloid-β peptide (Aβ) toxicity by modulating the tyrosine kinase Fyn. We s...

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Main Authors: Roberson, Erik D., Halabisky, Brian, Yoo, Jong W., Yao, Jinghua, Chin, Jeannie, Yan, Fengrong, Wu, Tiffany, Hamto, Patricia, Devidze, Nino, Yu, Gui-Qiu, Palop, Jorge J., Noebels, Jeffrey L., Mucke, Lennart
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3325794/
https://ncbi.nlm.nih.gov/pubmed/21228179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4152-10.2011
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