CR8, a Selective and Potent CDK Inhibitor, Provides Neuroprotection in Experimental Traumatic Brain Injury

Traumatic brain injury (TBI) induces secondary injury mechanisms, including cell cycle activation (CCA), that leads to neuronal death and neurological dysfunction. We recently reported that delayed administration of roscovitine, a relatively selective cyclin-dependent kinase (CDK) inhibitor, inhibit...

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Hlavní autoři: Kabadi, Shruti V., Stoica, Bogdan A., Hanscom, Marie, Loane, David J., Kharebava, Giorgi, Murray II, Michael G., Cabatbat, Rainier M., Faden, Alan I.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer-Verlag 2011
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3324621/
https://ncbi.nlm.nih.gov/pubmed/22167461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13311-011-0095-4
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