CR8, a Selective and Potent CDK Inhibitor, Provides Neuroprotection in Experimental Traumatic Brain Injury

Traumatic brain injury (TBI) induces secondary injury mechanisms, including cell cycle activation (CCA), that leads to neuronal death and neurological dysfunction. We recently reported that delayed administration of roscovitine, a relatively selective cyclin-dependent kinase (CDK) inhibitor, inhibit...

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Autori principali: Kabadi, Shruti V., Stoica, Bogdan A., Hanscom, Marie, Loane, David J., Kharebava, Giorgi, Murray II, Michael G., Cabatbat, Rainier M., Faden, Alan I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer-Verlag 2011
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3324621/
https://ncbi.nlm.nih.gov/pubmed/22167461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13311-011-0095-4
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