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CR8, a novel inhibitor of CDK, limits microglial activation, astrocytosis, neuronal loss, and neurologic dysfunction after experimental traumatic brain injury

Central nervous system injury causes a marked increase in the expression of cell cycle-related proteins. In this study, we show that cell cycle activation (CCA) is detected in mature neurons at 24 hours after rat lateral fluid percussion (LFP)-induced traumatic brain injury (TBI), as reflected by in...

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Autori principali: Kabadi, Shruti V, Stoica, Bogdan A, Loane, David J, Luo, Tao, Faden, Alan I
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3948132/
https://ncbi.nlm.nih.gov/pubmed/24398934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2013.228
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