PARP-1 Inhibition Attenuates Neuronal Loss, Microglia Activation and Neurological Deficits after Traumatic Brain Injury

Traumatic brain injury (TBI) causes neuronal cell death as well as microglial activation and related neurotoxicity that contribute to subsequent neurological dysfunction. Poly (ADP-ribose) polymerase (PARP-1) induces neuronal cell death through activation of caspase-independent mechanisms, including...

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Detalhes bibliográficos
Main Authors: Stoica, Bogdan A., Loane, David J., Zhao, Zaorui, Kabadi, Shruti V., Hanscom, Marie, Byrnes, Kimberly R., Faden, Alan I.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2014
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3967421/
https://ncbi.nlm.nih.gov/pubmed/24476502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/neu.2013.3194
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