PARP-1 Inhibition Attenuates Neuronal Loss, Microglia Activation and Neurological Deficits after Traumatic Brain Injury

Traumatic brain injury (TBI) causes neuronal cell death as well as microglial activation and related neurotoxicity that contribute to subsequent neurological dysfunction. Poly (ADP-ribose) polymerase (PARP-1) induces neuronal cell death through activation of caspase-independent mechanisms, including...

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Autores principales: Stoica, Bogdan A., Loane, David J., Zhao, Zaorui, Kabadi, Shruti V., Hanscom, Marie, Byrnes, Kimberly R., Faden, Alan I.
Formato: Artigo
Lenguaje:Inglês
Publicado: Mary Ann Liebert, Inc. 2014
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3967421/
https://ncbi.nlm.nih.gov/pubmed/24476502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/neu.2013.3194
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