CFTR regulation in human airway epithelial cells requires integrity of the actin cytoskeleton and compartmentalized cAMP and PKA activity

The cystic fibrosis transmembrane conductance regulator (CFTR) mutation ΔF508CFTR still causes regulatory defects when rescued to the apical membrane, suggesting that the intracellular milieu might affect its ability to respond to cAMP regulation. We recently reported that overexpression of the Na(+...

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Main Authors: Monterisi, Stefania, Favia, Maria, Guerra, Lorenzo, Cardone, Rosa A., Marzulli, Domenico, Reshkin, Stephan J., Casavola, Valeria, Zaccolo, Manuela
Formato: Artigo
Idioma:Inglês
Publicado: Company of Biologists 2012
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Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3324578/
https://ncbi.nlm.nih.gov/pubmed/22302988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.089086
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