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Whole-Cell cAMP and PKA Activity are Epiphenomena, Nanodomain Signaling Matters
Novel targeted fluorescent biosensors provide key insights into very local nanodomains of cAMP and PKA activity, and how they respond differently to β-adrenergic activation in cardiac myocytes. This unique spatiotemporal detail in living cells is not available with biochemical measurements of total...
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| 出版年: | Physiology (Bethesda) |
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| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Physiological Society
2019
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6863374/ https://ncbi.nlm.nih.gov/pubmed/31165682 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/physiol.00002.2019 |
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