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Whole-Cell cAMP and PKA Activity are Epiphenomena, Nanodomain Signaling Matters

Novel targeted fluorescent biosensors provide key insights into very local nanodomains of cAMP and PKA activity, and how they respond differently to β-adrenergic activation in cardiac myocytes. This unique spatiotemporal detail in living cells is not available with biochemical measurements of total...

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Detalhes bibliográficos
Publicado no:Physiology (Bethesda)
Main Authors: Bers, Donald M., Xiang, Yang K., Zaccolo, Manuela
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6863374/
https://ncbi.nlm.nih.gov/pubmed/31165682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/physiol.00002.2019
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