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Whole-Cell cAMP and PKA Activity are Epiphenomena, Nanodomain Signaling Matters

Novel targeted fluorescent biosensors provide key insights into very local nanodomains of cAMP and PKA activity, and how they respond differently to β-adrenergic activation in cardiac myocytes. This unique spatiotemporal detail in living cells is not available with biochemical measurements of total...

詳細記述

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書誌詳細
出版年:Physiology (Bethesda)
主要な著者: Bers, Donald M., Xiang, Yang K., Zaccolo, Manuela
フォーマット: Artigo
言語:Inglês
出版事項: American Physiological Society 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6863374/
https://ncbi.nlm.nih.gov/pubmed/31165682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/physiol.00002.2019
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