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Whole-Cell cAMP and PKA Activity are Epiphenomena, Nanodomain Signaling Matters

Novel targeted fluorescent biosensors provide key insights into very local nanodomains of cAMP and PKA activity, and how they respond differently to β-adrenergic activation in cardiac myocytes. This unique spatiotemporal detail in living cells is not available with biochemical measurements of total...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Physiology (Bethesda)
Prif Awduron: Bers, Donald M., Xiang, Yang K., Zaccolo, Manuela
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Physiological Society 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6863374/
https://ncbi.nlm.nih.gov/pubmed/31165682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/physiol.00002.2019
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