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CYP3A5 genotype does not influence everolimus in vitro metabolism and clinical pharmacokinetics in renal transplant recipients

BACKGROUND: CYP3A5 genotyping might be useful to guide tacrolimus and sirolimus dosing. The aim of this study was to assess the influence of CYP3A5 polymorphism on everolimus metabolism and pharmacokinetics. METHODS: We investigated the effect of CYP3A5 A6986G polymorphism (CYP3A5*1/*3 alleles) on t...

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Detalhes bibliográficos
Main Authors: Picard, Nicolas, Rouguieg-Malki, Koukeb, Kamar, Nassim, Rostaing, Lionel, Marquet, Pierre
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3324087/
https://ncbi.nlm.nih.gov/pubmed/21389905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TP.0b013e31820ae4ac
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