Effect of CYP3A4*22, CYP3A5*3, and CYP3A Combined Genotypes on Cyclosporine, Everolimus, and Tacrolimus Pharmacokinetics in Renal Transplantation

Cyclosporine, everolimus, and tacrolimus are the cornerstone of immunosuppressive therapy in renal transplantation. These drugs are characterized by narrow therapeutic windows, highly variable pharmacokinetics (PK), and metabolism by CYP3A enzymes. Recently, the decreased activity allele, CYP3A4*22,...

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Main Authors: Moes, D J A R, Swen, J J, den Hartigh, J, van der Straaten, T, van der Heide, J J Homan, Sanders, J S, Bemelman, F J, de Fijter, J W, Guchelaar, H J
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2014
Ábhair:
Original Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3944116/
https://ncbi.nlm.nih.gov/pubmed/24522145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/psp.2013.78
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