Population pharmacokinetics and pharmacogenetics of once daily tacrolimus formulation in stable liver transplant recipients

PURPOSE: The once daily formulation of tacrolimus is an important immunosuppressive drug. Interpatient variability in metabolism has been related to genetic variation in CYP3A4 and CYP3A5. However, in liver transplantation, both donor and recipient genotypes may affect pharmacokinetics. The primary...

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Publicado en:Eur J Clin Pharmacol
Autores principales: Moes, D. J. A. R, van der Bent, S. A. S, Swen, J. J., van der Straaten, T., Inderson, A., Olofsen, E., Verspaget, H. W., Guchelaar, H. J., den Hartigh, J., van Hoek, B.
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer Berlin Heidelberg 2015
Materias:
Pharmacogenetics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4713720/
https://ncbi.nlm.nih.gov/pubmed/26521259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00228-015-1963-3
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