Population pharmacokinetics and pharmacogenetics of once daily tacrolimus formulation in stable liver transplant recipients

PURPOSE: The once daily formulation of tacrolimus is an important immunosuppressive drug. Interpatient variability in metabolism has been related to genetic variation in CYP3A4 and CYP3A5. However, in liver transplantation, both donor and recipient genotypes may affect pharmacokinetics. The primary...

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Detalles Bibliográficos
Publicado en:Eur J Clin Pharmacol
Main Authors: Moes, D. J. A. R, van der Bent, S. A. S, Swen, J. J., van der Straaten, T., Inderson, A., Olofsen, E., Verspaget, H. W., Guchelaar, H. J., den Hartigh, J., van Hoek, B.
Formato: Artigo
Idioma:Inglês
Publicado: Springer Berlin Heidelberg 2015
Assuntos:
Pharmacogenetics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4713720/
https://ncbi.nlm.nih.gov/pubmed/26521259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00228-015-1963-3
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