The influence of CYP3A, PPARA, and POR genetic variants on the pharmacokinetics of tacrolimus and cyclosporine in renal transplant recipients

PURPOSE: Tacrolimus (Tac) and cyclosporine (CsA) are mainly metabolized by CYP3A4 and CYP3A5. Several studies have demonstrated an association between the CYP3A5 genotype and Tac dose requirements. Recently, CYP3A4, PPARA, and POR gene variants have been shown to influence CYP3A metabolism. The pres...

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Detalhes bibliográficos
Main Authors: Lunde, Ingrid, Bremer, Sara, Midtvedt, Karsten, Mohebi, Beata, Dahl, Miriam, Bergan, Stein, Åsberg, Anders, Christensen, Hege
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2014
Assuntos:
Pharmacogenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025175/
https://ncbi.nlm.nih.gov/pubmed/24658827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00228-014-1656-3
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