The influence of CYP3A, PPARA, and POR genetic variants on the pharmacokinetics of tacrolimus and cyclosporine in renal transplant recipients

PURPOSE: Tacrolimus (Tac) and cyclosporine (CsA) are mainly metabolized by CYP3A4 and CYP3A5. Several studies have demonstrated an association between the CYP3A5 genotype and Tac dose requirements. Recently, CYP3A4, PPARA, and POR gene variants have been shown to influence CYP3A metabolism. The pres...

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Hlavní autoři: Lunde, Ingrid, Bremer, Sara, Midtvedt, Karsten, Mohebi, Beata, Dahl, Miriam, Bergan, Stein, Åsberg, Anders, Christensen, Hege
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Berlin Heidelberg 2014
Témata:
Pharmacogenetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025175/
https://ncbi.nlm.nih.gov/pubmed/24658827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00228-014-1656-3
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