M phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical association with the deubiquitylase USP7 and stability

UHRF1 (Ubiquitin-like, with PHD and RING finger domains 1) plays an important role in DNA CpG methylation, heterochromatin function and gene expression. Overexpression of UHRF1 has been suggested to contribute to tumorigenesis. However, regulation of UHRF1 is largely unknown. Here we show that the d...

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Detalhes bibliográficos
Main Authors: Ma, Honghui, Chen, Hao, Guo, Xue, Wang, Zhentian, Sowa, Mathew E., Zheng, Lijuan, Hu, Shibin, Zeng, Pingyao, Guo, Rui, Diao, Jianbo, Lan, Fei, Harper, J. Wade, Shi, Yujiang Geno, Xu, Yanhui, Shi, Yang
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3323953/
https://ncbi.nlm.nih.gov/pubmed/22411829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1116349109
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