Nuclear Targeting of IGF-1 Receptor in Orbital Fibroblasts from Graves' Disease: Apparent Role of ADAM17

Insulin-like growth factor-1 receptor (IGF-1R) comprises two subunits, including a ligand binding domain on extra- cellular IGF-1Rα and a tyrosine phosphorylation site located on IGF-1Rβ. IGF-1R is over-expressed by orbital fibroblasts in the autoimmune syndrome, Graves' disease (GD). When acti...

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Detalhes bibliográficos
Main Authors: Hoa, Neil, Tsui, Shanli, Afifiyan, Nikoo F., Sinha Hikim, Amiya, Li, Bin, Douglas, Raymond S., Smith, Terry J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3323600/
https://ncbi.nlm.nih.gov/pubmed/22506015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034173
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