Insights into Hemoglobin Assembly through in Vivo Mutagenesis of α-Hemoglobin Stabilizing Protein

α-Hemoglobin stabilizing protein (AHSP) is believed to facilitate adult Hemoglobin A assembly and protect against toxic free α-globin subunits. Recombinant AHSP binds multiple forms of free α-globin to stabilize their structures and inhibit precipitation. However, AHSP also stimulates autooxidation...

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Detalhes bibliográficos
Main Authors: Khandros, Eugene, Mollan, Todd L., Yu, Xiang, Wang, Xiaomei, Yao, Yu, D'Souza, Janine, Gell, David A., Olson, John S., Weiss, Mitchell J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3322894/
https://ncbi.nlm.nih.gov/pubmed/22287545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.313205
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