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Present and Future of EGFR Inhibitors for Head and Neck Squamous Cell Cancer

Although EGFR is expressed at high levels in head and neck squamous cell carcinomas (HNSCCs) and mutations are extremely rare, monotherapy with EGFR inhibitors has shown limited success. The PI3kinase/Akt pathway is responsible for cellular survival, and inhibition of phosphatidylinositol (PI) synth...

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Bibliografiske detaljer
Main Authors: Baba, Yuh, Fujii, Masato, Tokumaru, Yutaka, Kato, Yasumasa
Format: Artigo
Sprog:Inglês
Udgivet: Hindawi Publishing Corporation 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3321461/
https://ncbi.nlm.nih.gov/pubmed/22545054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/986725
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