Present and Future of EGFR Inhibitors for Head and Neck Squamous Cell Cancer

Although EGFR is expressed at high levels in head and neck squamous cell carcinomas (HNSCCs) and mutations are extremely rare, monotherapy with EGFR inhibitors has shown limited success. The PI3kinase/Akt pathway is responsible for cellular survival, and inhibition of phosphatidylinositol (PI) synth...

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Detalles Bibliográficos
Main Authors: Baba, Yuh, Fujii, Masato, Tokumaru, Yutaka, Kato, Yasumasa
Formato: Artigo
Idioma:Inglês
Publicado: Hindawi Publishing Corporation 2012
Assuntos:
Review Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3321461/
https://ncbi.nlm.nih.gov/pubmed/22545054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/986725
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