Identification of Novel γ-Secretase-associated Proteins in Detergent-resistant Membranes from Brain

In Alzheimer disease, oligomeric amyloid β-peptide (Aβ) species lead to synapse loss and neuronal death. γ-Secretase, the transmembrane protease complex that mediates the final catalytic step that liberates Aβ from its precursor protein (APP), has a multitude of substrates, and therapeutics aimed at...

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Detalles Bibliográficos
Autores principales: Hur, Ji-Yeun, Teranishi, Yasuhiro, Kihara, Takahiro, Yamamoto, Natsuko Goto, Inoue, Mitsuhiro, Hosia, Waltteri, Hashimoto, Masakazu, Winblad, Bengt, Frykman, Susanne, Tjernberg, Lars O.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Neurobiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3320946/
https://ncbi.nlm.nih.gov/pubmed/22315232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.246074
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