2′-O Methylation of Internal Adenosine by Flavivirus NS5 Methyltransferase

RNA modification plays an important role in modulating host-pathogen interaction. Flavivirus NS5 protein encodes N-7 and 2′-O methyltransferase activities that are required for the formation of 5′ type I cap (m(7)GpppAm) of viral RNA genome. Here we reported, for the first time, that flavivirus NS5...

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Detalhes bibliográficos
Main Authors: Dong, Hongping, Chang, David C., Hua, Maggie Ho Chia, Lim, Siew Pheng, Chionh, Yok Hian, Hia, Fabian, Lee, Yie Hou, Kukkaro, Petra, Lok, Shee-Mei, Dedon, Peter C., Shi, Pei-Yong
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3320599/
https://ncbi.nlm.nih.gov/pubmed/22496660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002642
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