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A Substrate Pharmacophore for the Human Organic Cation/Carnitine Transporter Identifies Compounds Associated with Rhabdomyolysis

The human Organic Cation/Carnitine Transporter (hOCTN2), is a high affinity cation/carnitine transporter expressed widely in human tissues and is physiologically important for the homeostasis of L-carnitine. The objective of this study was to elucidate the substrate requirements of this transporter...

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Main Authors: Ekins, Sean, Diao, Lei, Polli, James E.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3319199/
https://ncbi.nlm.nih.gov/pubmed/22339151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp200438v
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