PGV04, an HIV-1 gp120 CD4 Binding Site Antibody, Is Broad and Potent in Neutralization but Does Not Induce Conformational Changes Characteristic of CD4

Recently, several broadly neutralizing monoclonal antibodies (bnMAbs) directed to the CD4-binding site (CD4bs) of gp120 have been isolated from HIV-1-positive donors. These include VRC01, 3BNC117, and NIH45-46, all of which are capable of neutralizing about 90% of circulating HIV-1 isolates and all...

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Main Authors: Falkowska, Emilia, Ramos, Alejandra, Feng, Yu, Zhou, Tongqing, Moquin, Stephanie, Walker, Laura M., Wu, Xueling, Seaman, Michael S., Wrin, Terri, Kwong, Peter D., Wyatt, Richard T., Mascola, John R., Poignard, Pascal, Burton, Dennis R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2012
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318667/
https://ncbi.nlm.nih.gov/pubmed/22345481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06973-11
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