Outer Domain of HIV-1 gp120: Antigenic Optimization, Structural Malleability, and Crystal Structure with Antibody VRC-PG04

The outer domain of the HIV-1 gp120 envelope glycoprotein contains the epitope for broadly neutralizing antibodies directed to the CD4-binding site, many of which are able to neutralize over 90% of circulating HIV-1 isolates. While the outer domain is conformationally more stable than other portions...

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Hlavní autoři: Joyce, M. Gordon, Kanekiyo, Masaru, Xu, Ling, Biertümpfel, Christian, Boyington, Jeffrey C., Moquin, Stephanie, Shi, Wei, Wu, Xueling, Yang, Yongping, Yang, Zhi-Yong, Zhang, Baoshan, Zheng, Anqi, Zhou, Tongqing, Zhu, Jiang, Mascola, John R., Kwong, Peter D., Nabel, Gary J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2013
Témata:
Structure and Assembly
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3571475/
https://ncbi.nlm.nih.gov/pubmed/23236069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02717-12
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