Crystal Structure of PG16 and Chimeric Dissection with Somatically Related PG9: Structure-Function Analysis of Two Quaternary-Specific Antibodies That Effectively Neutralize HIV-1

HIV-1 resists neutralization by most antibodies. Two somatically related human antibodies, PG9 and PG16, however, each neutralize 70 to 80% of circulating HIV-1 isolates. Here we present the structure of the antigen-binding fragment of PG16 in monoclinic and orthorhombic lattices at 2.4 and 4.0 Å, r...

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Autors principals: Pancera, Marie, McLellan, Jason S., Wu, Xueling, Zhu, Jiang, Changela, Anita, Schmidt, Stephen D., Yang, Yongping, Zhou, Tongqing, Phogat, Sanjay, Mascola, John R., Kwong, Peter D.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2010
Matèries:
Pathogenesis and Immunity
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2916520/
https://ncbi.nlm.nih.gov/pubmed/20538861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00966-10
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