Crystal Structure of Human Antibody 2909 Reveals Conserved Features of Quaternary Structure-Specific Antibodies That Potently Neutralize HIV-1

Monoclonal antibody 2909 belongs to a class of potently neutralizing antibodies that recognize quaternary epitopes on HIV-1. Some members of this class, such as 2909, are strain specific, while others, such as antibody PG16, are broadly neutralizing; all, however, recognize a region on the gp120 env...

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Detalhes bibliográficos
Main Authors: Changela, Anita, Wu, Xueling, Yang, Yongping, Zhang, Baoshan, Zhu, Jiang, Nardone, Glenn A., O'Dell, Sijy, Pancera, Marie, Gorny, Miroslaw K., Phogat, Sanjay, Robinson, James E., Stamatatos, Leonidas, Zolla-Pazner, Susan, Mascola, John R., Kwong, Peter D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2011
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067962/
https://ncbi.nlm.nih.gov/pubmed/21191009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02335-10
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