Antiretroviral Therapy Reduces the Magnitude and T Cell Receptor Repertoire Diversity of HIV-Specific T Cell Responses without Changing T Cell Clonotype Dominance

After initiation of antiretroviral therapy (ART), HIV loads and frequencies of HIV epitope-specific immune responses decrease. A diverse virus-specific T cell receptor (TCR) repertoire allows the host to respond to viral epitope diversity, but the effect of antigen reduction as a result of ART on th...

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Detalhes bibliográficos
Main Authors: Conrad, Joseph A., Ramalingam, Ramesh K., Duncan, Coley B., Smith, Rita M., Wei, Jie, Barnett, Louise, Simons, Brenna C., Lorey, Shelly L., Kalams, Spyros A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318638/
https://ncbi.nlm.nih.gov/pubmed/22258246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06000-11
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