Dominant clonotypes within HIV-specific T cell responses are PD-1(hi) and CD127(low) and display reduced variant cross-reactivity

HIV-epitope-specific T cell responses are often comprised of clonotypic expansions with distinct functional properties. In HIV+ individuals, we measured PD-1 and IL-7Rα expression, MHC-I tetramer binding, cytokine production, and proliferation profiles of dominant and sub-dominant T cell receptor cl...

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Main Authors: Conrad, Joseph A., Ramalingam, Ramesh K., Smith, Rita M., Barnett, Louise, Lorey, Shelly L., Wei, Jie, Simons, Brenna C., Sadagopal, Shanmugalakshmi, Meyer-Olson, Dirk, Kalams, Spyros A.
Format: Artigo
Language:Inglês
Published: 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3403726/
https://ncbi.nlm.nih.gov/pubmed/21562156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1004234
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