Clonal expansion and TCR-independent differentiation shape the HIV-specific CD8(+) effector-memory T-cell repertoire in vivo

Flexibility of the HIV-specific T-cell receptor repertoire is a hallmark of HIV-1 infection. Altered differentiation of HIV-specific CD45RO(+)/CCR7(−) (TemRO) CD8(+) effector-memory T cells into CD45RA(+)/CCR7(−) (TemRA) CD8(+) effector-memory T cells as well as increased expression of the senescenc...

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Detalhes bibliográficos
Main Authors: Meyer-Olson, Dirk, Simons, Brenna C., Conrad, Joseph A., Smith, Rita M., Barnett, Louise, Lorey, Shelly L., Duncan, Coley B., Ramalingam, Ramesh, Kalams, Spyros A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2913459/
https://ncbi.nlm.nih.gov/pubmed/20424187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-11-254136
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