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Fluctuations of functionally distinct CD8(+) T-cell clonotypes demonstrate flexibility of the HIV-specific TCR repertoire

T-cell receptor (TCR) diversity of virus-specific CD8(+) T cells likely helps prevent escape mutations in chronic viral infections. To understand the dynamics of the virus-specific T cells in more detail, we followed the evolution of the TCR repertoire specific for a dominant HLA-B*08–restricted epi...

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Detalhes bibliográficos
Main Authors: Meyer-Olson, Dirk, Brady, Kristen W., Bartman, Melissa T., O'Sullivan, Kristin M., Simons, Brenna C., Conrad, Joseph A., Duncan, Coley B., Lorey, Shelly, Siddique, Atif, Draenert, Rika, Addo, Marylyn, Altfeld, Marcus, Rosenberg, Eric, Allen, Todd M., Walker, Bruce D., Kalams, Spyros A.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society of Hematology 2006
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895729/
https://ncbi.nlm.nih.gov/pubmed/16322475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-04-1636
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