TCR repertoire sequencing identifies synovial Treg cell clonotypes in the bloodstream during active inflammation in human arthritis

OBJECTIVES: The imbalance between effector and regulatory T (Treg) cells is crucial in the pathogenesis of autoimmune arthritis. Immune responses are often investigated in the blood because of its accessibility, but circulating lymphocytes are not representative of those found in inflamed tissues. T...

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Veröffentlicht in:Ann Rheum Dis
Hauptverfasser: Rossetti, Maura, Spreafico, Roberto, Consolaro, Alessandro, Leong, Jing Yao, Chua, Camillus, Massa, Margherita, Saidin, Suzan, Magni-Manzoni, Silvia, Arkachaisri, Thaschawee, Wallace, Carol A, Gattorno, Marco, Martini, Alberto, Lovell, Daniel J, Albani, Salvatore
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMJ Publishing Group 2017
Schlagworte:
Basic and Translational Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5284348/
https://ncbi.nlm.nih.gov/pubmed/27311837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2015-208992
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