TCR repertoire sequencing identifies synovial Treg cell clonotypes in the bloodstream during active inflammation in human arthritis

OBJECTIVES: The imbalance between effector and regulatory T (Treg) cells is crucial in the pathogenesis of autoimmune arthritis. Immune responses are often investigated in the blood because of its accessibility, but circulating lymphocytes are not representative of those found in inflamed tissues. T...

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Detalhes bibliográficos
Publicado no:Ann Rheum Dis
Main Authors: Rossetti, Maura, Spreafico, Roberto, Consolaro, Alessandro, Leong, Jing Yao, Chua, Camillus, Massa, Margherita, Saidin, Suzan, Magni-Manzoni, Silvia, Arkachaisri, Thaschawee, Wallace, Carol A, Gattorno, Marco, Martini, Alberto, Lovell, Daniel J, Albani, Salvatore
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2017
Assuntos:
Basic and Translational Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5284348/
https://ncbi.nlm.nih.gov/pubmed/27311837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2015-208992
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