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How many TCR clonotypes does a body maintain?

We consider the lifetime of a T cell clonotype, the set of T cells with the same T cell receptor, from its thymic origin to its extinction in a multiclonal repertoire. Using published estimates of total cell numbers and thymic production rates, we calculate the mean number of cells per TCR clonotype...

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Detalles Bibliográficos
Publicado en:J Theor Biol
Main Authors: Lythe, Grant, Callard, Robin E., Hoare, Rollo L., Molina-París, Carmen
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4678146/
https://ncbi.nlm.nih.gov/pubmed/26546971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtbi.2015.10.016
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