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How many TCR clonotypes does a body maintain?
We consider the lifetime of a T cell clonotype, the set of T cells with the same T cell receptor, from its thymic origin to its extinction in a multiclonal repertoire. Using published estimates of total cell numbers and thymic production rates, we calculate the mean number of cells per TCR clonotype...
Enregistré dans:
| Publié dans: | J Theor Biol |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Elsevier
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4678146/ https://ncbi.nlm.nih.gov/pubmed/26546971 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtbi.2015.10.016 |
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