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Ex vivo-expanded, but not in vitro-induced, human regulatory T cells are candidates for cell therapy in autoimmune diseases due to stable demethylation of the FOXP3 TSDR(a)

Treg cell therapy is a promising approach for transplant rejection and severe autoimmunity. Unfortunately, clinically meaningful Treg numbers can be obtained only upon in vitro culture. Functional stability of human expanded (e)Tregs and induced (i)Tregs has not been thoroughly addressed for all pro...

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Bibliografiske detaljer
Udgivet i:J Immunol
Main Authors: Rossetti, Maura, Spreafico, Roberto, Saidin, Suzan, Chua, Camillus, Moshref, Maryam, Leong, Jing Yao, Tan, York Kiat, Thumboo, Julian, van Loosdregt, Jorg, Albani, Salvatore
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4383769/
https://ncbi.nlm.nih.gov/pubmed/25452562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401145
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