Cellular prion protein participates in amyloid-β transcytosis across the blood–brain barrier

The blood–brain barrier (BBB) facilitates amyloid-β (Aβ) exchange between the blood and the brain. Here, we found that the cellular prion protein (PrP(c)), a putative receptor implicated in mediating Aβ neurotoxicity in Alzheimer's disease (AD), participates in Aβ transcytosis across the BBB. U...

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Detalhes bibliográficos
Main Authors: Pflanzner, Thorsten, Petsch, Benjamin, André-Dohmen, Bettina, Müller-Schiffmann, Andreas, Tschickardt, Sabrina, Weggen, Sascha, Stitz, Lothar, Korth, Carsten, Pietrzik, Claus U
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Brief Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318156/
https://ncbi.nlm.nih.gov/pubmed/22293988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2012.7
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