Endothelial LRP1 transports amyloid-β(1–42) across the blood-brain barrier

According to the neurovascular hypothesis, impairment of low-density lipoprotein receptor–related protein-1 (LRP1) in brain capillaries of the blood-brain barrier (BBB) contributes to neurotoxic amyloid-β (Aβ) brain accumulation and drives Alzheimer’s disease (AD) pathology. However, due to conflict...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Storck, Steffen E., Meister, Sabrina, Nahrath, Julius, Meißner, Julius N., Schubert, Nils, Di Spiezio, Alessandro, Baches, Sandra, Vandenbroucke, Roosmarijn E., Bouter, Yvonne, Prikulis, Ingrid, Korth, Carsten, Weggen, Sascha, Heimann, Axel, Schwaninger, Markus, Bayer, Thomas A., Pietrzik, Claus U.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4701557/
https://ncbi.nlm.nih.gov/pubmed/26619118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI81108
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