Distamycins inhibit the binding of OTF-1 and NFE-1 transfactors to their conserved DNA elements.

We investigated the effects of the antiviral agent distamycin A and of a distamycin derivative (FCE 24517) which possesses antineoplastic activity on the binding of some regulatory proteins to DNA. Both compounds inhibited the binding to DNA of the ubiquitous octamer binding factor OTF 1 and of the...

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Publié dans:	Nucleic Acids Res
Auteurs principaux:	Broggini, M, Ponti, M, Ottolenghi, S, D'Incalci, M, Mongelli, N, Mantovani, R
Format:	Artigo
Langue:	Inglês
Publié:	Oxford University Press 1989
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC331721/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2922260/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/17.3.1051
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