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Distamycins inhibit the binding of OTF-1 and NFE-1 transfactors to their conserved DNA elements.

We investigated the effects of the antiviral agent distamycin A and of a distamycin derivative (FCE 24517) which possesses antineoplastic activity on the binding of some regulatory proteins to DNA. Both compounds inhibited the binding to DNA of the ubiquitous octamer binding factor OTF 1 and of the...

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Udgivet i:Nucleic Acids Res
Principais autores: Broggini, M, Ponti, M, Ottolenghi, S, D'Incalci, M, Mongelli, N, Mantovani, R
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 1989
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC331721/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2922260/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/17.3.1051
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