Quantitative Proteomics Reveals That Hsp90 Inhibition Preferentially Targets Kinases and the DNA Damage Response

Despite the increasing importance of heat shock protein 90 (Hsp90) inhibitors as chemotherapeutic agents in diseases such as cancer, their global effects on the proteome remain largely unknown. Here we use high resolution, quantitative mass spectrometry to map protein expression changes associated w...

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Bibliographische Detailangaben
Hauptverfasser: Sharma, Kirti, Vabulas, R. Martin, Macek, Boris, Pinkert, Stefan, Cox, Jürgen, Mann, Matthias, Hartl, F. Ulrich
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
Special Issue: Prospects in Space and Time
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3316734/
https://ncbi.nlm.nih.gov/pubmed/22167270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M111.014654
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